Actividades biológicas de Guazuma ulmifolia: una revisión
DOI:
https://doi.org/10.15648/invefor.v4i1.4133Palabras clave:
Actividad biológica, extracto vegetal, Guazuma ulmifoliaResumen
Guazuma ulmifolia (Malvaceae) es una especie nativa de América Central que se extiende hasta América del Sur, donde reportan diversos usos tradicionales en hojas y corteza asociados a reducción de peso y como tratamiento para diversas patologías, propiedades atribuidas a constituyentes tipo fenoles. La revisión documental se realizó a través de palabras claves en diferentes bases de datos de revistas indexadas. Se identificaron actividades de tipo antioxidantes, gastroprotectoras, nefroprotectoras, antidiabéticas, antiobesidad, antiviral, antibacterianas, antifúngicas, antihelmínticas, antiinflamatoria, antihipertensiva y cicatrizante. Esta especie reporta muchas propiedades documentadas, que tienen gran potencial para el desarrollo de nuevas sustancias bioactivas y generación de nuevos productos fitoterapéuticos, mostrando un potencial para el desarrollo de nuevos temas de investigación relacionados con mecanismos de acción, constituyentes responsables de actividades biológicas o nuevos campos de estudio.
Biografía del autor/a
Mónica Suárez Gutiérrez, Universidad del Atlántico
Semillero Grupo de Investigación Fitoquímica (GIF-UdelA)
Jhon Aceros Ramírez, Universidad del Atlántico
Semillero Grupo de Investigación Fitoquímica (GIF-UdelA)
Oscar Camacho Romero, Universidad del Atlántico
Semillero Grupo de Investigación Fitoquímica (GIF-UdelA)
Referencias bibliográficas
Alonso-Castro, A. J., & Salazar-Olivo, L. A. (2008). The anti-diabetic properties of Guazuma ulmifolia Lam are mediated by the stimulation of glucose uptake in normal and diabetic adipocytes without inducing adipogenesis. Journal of Ethnopharmacology, 118(2), 252–256. https://doi.org/10.1016/J.JEP.2008.04.007
Araujo, G., Arruda, H. S., de Morais, D. R., Peixoto Araujo, N. M., & Pastore, G. M. (2020). Mutamba (Guazuma ulmifolia Lam.) fruit as a novel source of dietary fibre and phenolic compounds. Food Chemistry, 310. https://doi.org/10.1016/j.foodchem.2019.125857
Araujo, L., Nunes, K., Mello, J., Nakamura, C., Gomes, R., & Bergamasco, R. (2024). Evaluation of the antioxidant, photoprotective and wound healing capacity of Guazuma ulmifolia lam. Extracts in L-929 cells exposed to UV-A and UV-B irradiation. Journal of the Brazilian Chemical Society. https://doi.org/10.21577/0103-5053.20230149
Berenguer, B., Trabadela, C., Sánchez-Fidalgo, S., Quílez, A., Miño, P., De la Puerta, R., & Martín-Calero, M. J. (2007). The aerial parts of Guazuma ulmifolia Lam. protect against NSAID-induced gastric lesions. Journal of Ethnopharmacology, 114(2), 153–160. https://doi.org/10.1016/J.JEP.2007.07.019
Caballero-George, C., Vanderheyden, P. M., De Bruyne, T., Shahat, A. A., Van den Heuvel, H., Solis, P. N., Gupta, M. P., Claeys, M., Pieters, L., Vauquelin, G., & Vlietinck, A. J. (2002). In vitro inhibition of [3H]-angiotensin II binding on the human AT1 receptor by proanthocyanidins from Guazuma ulmifolia bark. Planta medica, 68(12), 1066–1071. https://doi.org/10.1055/s-2002-36344
Castro Martínez, P. A., León González, J. A., & Sanjuanelo Corredor, D. W. (2023). Evaluación in vitro de la actividad antihelmíntica de extractos metanólicos de Guazuma ulmifolia frente a nematodos Cyathostominae. Revista de Investigaciones Veterinarias Del Perú, 34(1), e22852. https://doi.org/10.15381/rivep.v34i1.22852
Comisión nacional para el conocimiento y uso de la biodiversidad (CONABIO). 2014. Guazuma ulmifolia Lam. http://www.conabio.gob.mx/conocimiento/info_especies/arboles/doctos/66-sterc1m.pdf. (6 de enero de 2024).
Cunha, E. L., Barros, S. S. O., Perim, M. C., Santos, K. M. dos, Martins, M. L., & Nascimento, G. N. L. do. (2019). Biological Activity of Guazuma ulmifolia Lamark.- Systematic Review. Desafios. Revista Interdisciplinar da Universidade Federal do Tocantins, 6(3), 54–65. https://doi.org/10.20873/uftv6-6006
Do, Q. D., Angkawijaya, A. E., Tran-Nguyen, P. L., Huynh, L. H., Soetaredjo, F. E., Ismadji, S., & Ju, Y. H. (2014). Effect of extraction solvent on total phenol content, total flavonoid content, and antioxidant activity of Limnophila aromatica. Journal of food and drug analysis, 22(3), 296–302. https://doi.org/10.1016/j.jfda.2013.11.001
Dos Santos, J. M., Alfredo, T. M., Antunes, K. Á., da Cunha, J. da S. M., Costa, E. M. A., Lima, E. S., Silva, D. B., Carollo, C. A., Schmitz, W. O., Boleti, A. P. de A., dos Santos, E. L., & de Picoli Souza, K. (2018). Guazuma ulmifolia Lam. Decreases Oxidative Stress in Blood Cells and Prevents Doxorubicin-Induced Cardiotoxicity. Oxidative Medicine and Cellular Longevity, 2018, 1–16. https://doi.org/10.1155/2018/2935051
Elisa, H., Salcedo, R., Virgen-Calleros, G., De, J., Vargas-Radillo, J., Salcedo-Pérez, E., & Barrientos-Ramírez, L. (2015). Actividad antimicrobiana in vitro de extractos de hoja de Guazuma ulmifolia Lam. contra fitopatógenos. Revista Mexicana de Ciencias Forestales, 6(27), 114–124. http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2007-11322015000100010&lng=es&nrm=iso&tlng=es
Felipe, A. M., Rincão, V. P., Benati, F. J., Linhares, R. E., Galina, K. J., de Toledo, C. E., Lopes, G. C., de Mello, J. C., & Nozawa, C. (2006). Antiviral effect of Guazuma ulmifolia and Stryphnodendron adstringens on poliovirus and bovine herpesvirus. Biological & pharmaceutical bulletin, 29(6), 1092–1095. https://doi.org/10.1248/bpb.29.1092
Fernandes, T., Fernandes, A., & Pimenta, C. (2005). Atividade Antimicrobiana das Plantas Plathymenia reticulata, Hymenaea courbaril E Guazuma ulmifolia. Revista de patologia tropical. https://scholar.googleusercontent.com/scholar?q=cache:SEF2gfTweTcJ:scholar.google.com/+guazuma+ulmifolia&hl=es&as_sdt=0,5
Hör, M., Heinrich, M., & Rimpler, H. (1996). Proanthocyanidin polymers with antisecretory activity and proanthocyanidin oligomers from Guazuma ulmifolia bark. Phytochemistry, 42(1), 109–119. https://doi.org/10.1016/0031-9422(95)00855-1
Iswantini, D., Silitonga, R. F., Martatilofa, E., & Darusman, L. K. (2011). Zingiber cassumunar, Guazuma ulmifolia, and Murraya paniculata Extracts as Antiobesity: In Vitro Inhibitory Effect on Pancreatic Lipase Activity. HAYATI Journal of Biosciences, 18(1), 6–10. https://doi.org/10.4308/HJB.18.1.6
Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy reviews, 4(8), 118–126. https://doi.org/10.4103/0973-7847.70902
Lopes, G. C., Rocha, J. C. B., Almeida, G. C. de, & Mello, J. C. P. de. (2009). Condensed Tannins from the bark of Guazuma ulmifolia Lam. (Sterculiaceae). Journal of the Brazilian Chemical Society, 20(6). https://doi.org/10.1590/S0103-50532009000600016
Magos, G. A., Mateos, J. C., Páez, E., Fernández, G., Lobato, C., Márquez, C., & Enríquez, R. G. (2008). Hypotensive and vasorelaxant effects of the procyanidin fraction from Guazuma ulmifolia bark in normotensive and hypertensive rats. Journal of Ethnopharmacology, 117(1), 58–68. https://doi.org/10.1016/J.JEP.2008.01.015
Maldini, M., Di Micco, S., Montoro, P., Darra, E., Mariotto, S., Bifulco, G., Pizza, C., & Piacente, S. (2013). Flavanocoumarins from Guazuma ulmifolia bark and evaluation of their affinity for STAT1. Phytochemistry, 86, 64–71. https://doi.org/10.1016/j.phytochem.2012.10.011
Morais, S. M., Calixto-Júnior, J. T., Ribeiro, L. M., Sousa, H. A., Silva, A. A. S., Figueiredo, F. G., Matias, E. F. F., Boligon, A. A., Athayde, M. L., Morais-Braga, M. F. B., & Coutinho, H. D. M. (2017). Phenolic composition and antioxidant, anticholinesterase and antibiotic-modulating antifungal activities of Guazuma ulmifolia Lam. (Malvaceae) ethanol extract. South African Journal of Botany, 110, 251–257. https://doi.org/10.1016/j.sajb.2016.08.003
Odabasoglu, F., Aslan, A., Cakir, A., Suleyman, H., Karagoz, Y., Bayir, Y., & Halici, M. (2005). Antioxidant activity, reducing power and total phenolic content of some lichen species. Fitoterapia, 76(2), 216–219. https://doi.org/10.1016/j.fitote.2004.05.012
Povoa-Violante, I. M. P., Hamerski, L., Garcez, W. S., Batista, A. L., Chang, M. R., Pott, V. J., & Garcez, F. R. (2012). Antimicrobial activity of some medicinal plants from the cerrado of the central-western region of Brazil. Brazilian Journal of Microbiology, 43(4), 1302–1308. https://doi.org/10.1590/S1517-83822012000400009
Prahastuti, S., Hidayat, M., Hasiana, S., Widowati, W., Amalia, A., Qodariah, R., Rizal, R., Kusuma, H. W., & Khoiriyah, Z. (2019). Ethanol extract of jati belanda (Guazuma ulmifolia L.) as therapy for chronic kidney disease in vitro model. Journal of Reports in Pharmaceutical Sciences, 8(2), 229–235. https://doi.org/10.4103/jrptps.JRPTPS_41_18
Rafi, M., Meitary, N., Anggraini-Septaningsih, D., & Bintang, M. (2020). Phytochemical Profile and Antioxidant Activity of Guazuma ulmifolia Leaves Extracts Using Different Solvent Extraction. Indonesian Journal of Pharmacy, 31(3), 171–180.
Rozqie, R., Diah, M., & Rukmi, W. (2014). The effect of Jati Belanda (Guazuma ulmifolia Lamk) leaves extract on histopathology of rat’s kidney. Tropical Medicine Journal, 2(1), 57–65.
Sanabria N., Utrera, N., (2022). Guácimo (Guazuma ulmifolia Lam): Fuente de Compuestos Bioactivos Beneficiosos para la Salud. Revista de Ciencia y Tecnología, 1(21), 115–126. https://scholar.googleusercontent.com/scholar?q=cache:a0lSXNDBkuIJ:scholar.google.com/+Guazuma+ulmifolia+usos+medicinales&hl=es&as_sdt=0,5
Senthil, P., Kumar, A. A., Manasa, M., Kumar, K. A., Sravanthi, K., & Deepa, D. (2011). Wound healing activity of alcoholic extract of “Guazuma ulmifolia” leaves on Albino Wistar rats. International Journal of Pharma and Bio Sciences, 2(4), 34–38.
Shekhawat, D.N. (2021). Guazuma Ulmifolia: A Review on its Traditional Uses, Phytochemistry and Pharmacology. International Journal of pharma and Bio Sciences, 12, 93-105.
Von Son-De Fernex, E., Alonso Díaz, M. Á., Mendoza de Gives, P., Valles de la Mora, B., Zamilpa, A., & González Cortazar, M. (2016). Actividad ovicida de extractos de cuatro especies de plantas contra el nematodo gastrointestinal Cooperia punctata. Veterinaria México OA, 3(2), 0–0. https://doi.org/10.21753/VMOA.3.2.365
Widowati, W., Prahastuti, S., Hidayat, M., Hasiana, S. T., Wahyudianingsih, R., Afifah, E., Kusuma, H. S. W., Rizal, R., & Subangkit, M. (2022). Protective Effect of Ethanolic Extract of Jati Belanda (Guazuma ulmifolia L.) by Inhibiting Oxidative Stress and Inflammatory Processes in Cisplatin-induced Nephrotoxicity in Rats. Pakistan Veterinary Journal, 42(3), 376–382.
Araujo, G., Arruda, H. S., de Morais, D. R., Peixoto Araujo, N. M., & Pastore, G. M. (2020). Mutamba (Guazuma ulmifolia Lam.) fruit as a novel source of dietary fibre and phenolic compounds. Food Chemistry, 310. https://doi.org/10.1016/j.foodchem.2019.125857
Araujo, L., Nunes, K., Mello, J., Nakamura, C., Gomes, R., & Bergamasco, R. (2024). Evaluation of the antioxidant, photoprotective and wound healing capacity of Guazuma ulmifolia lam. Extracts in L-929 cells exposed to UV-A and UV-B irradiation. Journal of the Brazilian Chemical Society. https://doi.org/10.21577/0103-5053.20230149
Berenguer, B., Trabadela, C., Sánchez-Fidalgo, S., Quílez, A., Miño, P., De la Puerta, R., & Martín-Calero, M. J. (2007). The aerial parts of Guazuma ulmifolia Lam. protect against NSAID-induced gastric lesions. Journal of Ethnopharmacology, 114(2), 153–160. https://doi.org/10.1016/J.JEP.2007.07.019
Caballero-George, C., Vanderheyden, P. M., De Bruyne, T., Shahat, A. A., Van den Heuvel, H., Solis, P. N., Gupta, M. P., Claeys, M., Pieters, L., Vauquelin, G., & Vlietinck, A. J. (2002). In vitro inhibition of [3H]-angiotensin II binding on the human AT1 receptor by proanthocyanidins from Guazuma ulmifolia bark. Planta medica, 68(12), 1066–1071. https://doi.org/10.1055/s-2002-36344
Castro Martínez, P. A., León González, J. A., & Sanjuanelo Corredor, D. W. (2023). Evaluación in vitro de la actividad antihelmíntica de extractos metanólicos de Guazuma ulmifolia frente a nematodos Cyathostominae. Revista de Investigaciones Veterinarias Del Perú, 34(1), e22852. https://doi.org/10.15381/rivep.v34i1.22852
Comisión nacional para el conocimiento y uso de la biodiversidad (CONABIO). 2014. Guazuma ulmifolia Lam. http://www.conabio.gob.mx/conocimiento/info_especies/arboles/doctos/66-sterc1m.pdf. (6 de enero de 2024).
Cunha, E. L., Barros, S. S. O., Perim, M. C., Santos, K. M. dos, Martins, M. L., & Nascimento, G. N. L. do. (2019). Biological Activity of Guazuma ulmifolia Lamark.- Systematic Review. Desafios. Revista Interdisciplinar da Universidade Federal do Tocantins, 6(3), 54–65. https://doi.org/10.20873/uftv6-6006
Do, Q. D., Angkawijaya, A. E., Tran-Nguyen, P. L., Huynh, L. H., Soetaredjo, F. E., Ismadji, S., & Ju, Y. H. (2014). Effect of extraction solvent on total phenol content, total flavonoid content, and antioxidant activity of Limnophila aromatica. Journal of food and drug analysis, 22(3), 296–302. https://doi.org/10.1016/j.jfda.2013.11.001
Dos Santos, J. M., Alfredo, T. M., Antunes, K. Á., da Cunha, J. da S. M., Costa, E. M. A., Lima, E. S., Silva, D. B., Carollo, C. A., Schmitz, W. O., Boleti, A. P. de A., dos Santos, E. L., & de Picoli Souza, K. (2018). Guazuma ulmifolia Lam. Decreases Oxidative Stress in Blood Cells and Prevents Doxorubicin-Induced Cardiotoxicity. Oxidative Medicine and Cellular Longevity, 2018, 1–16. https://doi.org/10.1155/2018/2935051
Elisa, H., Salcedo, R., Virgen-Calleros, G., De, J., Vargas-Radillo, J., Salcedo-Pérez, E., & Barrientos-Ramírez, L. (2015). Actividad antimicrobiana in vitro de extractos de hoja de Guazuma ulmifolia Lam. contra fitopatógenos. Revista Mexicana de Ciencias Forestales, 6(27), 114–124. http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2007-11322015000100010&lng=es&nrm=iso&tlng=es
Felipe, A. M., Rincão, V. P., Benati, F. J., Linhares, R. E., Galina, K. J., de Toledo, C. E., Lopes, G. C., de Mello, J. C., & Nozawa, C. (2006). Antiviral effect of Guazuma ulmifolia and Stryphnodendron adstringens on poliovirus and bovine herpesvirus. Biological & pharmaceutical bulletin, 29(6), 1092–1095. https://doi.org/10.1248/bpb.29.1092
Fernandes, T., Fernandes, A., & Pimenta, C. (2005). Atividade Antimicrobiana das Plantas Plathymenia reticulata, Hymenaea courbaril E Guazuma ulmifolia. Revista de patologia tropical. https://scholar.googleusercontent.com/scholar?q=cache:SEF2gfTweTcJ:scholar.google.com/+guazuma+ulmifolia&hl=es&as_sdt=0,5
Hör, M., Heinrich, M., & Rimpler, H. (1996). Proanthocyanidin polymers with antisecretory activity and proanthocyanidin oligomers from Guazuma ulmifolia bark. Phytochemistry, 42(1), 109–119. https://doi.org/10.1016/0031-9422(95)00855-1
Iswantini, D., Silitonga, R. F., Martatilofa, E., & Darusman, L. K. (2011). Zingiber cassumunar, Guazuma ulmifolia, and Murraya paniculata Extracts as Antiobesity: In Vitro Inhibitory Effect on Pancreatic Lipase Activity. HAYATI Journal of Biosciences, 18(1), 6–10. https://doi.org/10.4308/HJB.18.1.6
Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy reviews, 4(8), 118–126. https://doi.org/10.4103/0973-7847.70902
Lopes, G. C., Rocha, J. C. B., Almeida, G. C. de, & Mello, J. C. P. de. (2009). Condensed Tannins from the bark of Guazuma ulmifolia Lam. (Sterculiaceae). Journal of the Brazilian Chemical Society, 20(6). https://doi.org/10.1590/S0103-50532009000600016
Magos, G. A., Mateos, J. C., Páez, E., Fernández, G., Lobato, C., Márquez, C., & Enríquez, R. G. (2008). Hypotensive and vasorelaxant effects of the procyanidin fraction from Guazuma ulmifolia bark in normotensive and hypertensive rats. Journal of Ethnopharmacology, 117(1), 58–68. https://doi.org/10.1016/J.JEP.2008.01.015
Maldini, M., Di Micco, S., Montoro, P., Darra, E., Mariotto, S., Bifulco, G., Pizza, C., & Piacente, S. (2013). Flavanocoumarins from Guazuma ulmifolia bark and evaluation of their affinity for STAT1. Phytochemistry, 86, 64–71. https://doi.org/10.1016/j.phytochem.2012.10.011
Morais, S. M., Calixto-Júnior, J. T., Ribeiro, L. M., Sousa, H. A., Silva, A. A. S., Figueiredo, F. G., Matias, E. F. F., Boligon, A. A., Athayde, M. L., Morais-Braga, M. F. B., & Coutinho, H. D. M. (2017). Phenolic composition and antioxidant, anticholinesterase and antibiotic-modulating antifungal activities of Guazuma ulmifolia Lam. (Malvaceae) ethanol extract. South African Journal of Botany, 110, 251–257. https://doi.org/10.1016/j.sajb.2016.08.003
Odabasoglu, F., Aslan, A., Cakir, A., Suleyman, H., Karagoz, Y., Bayir, Y., & Halici, M. (2005). Antioxidant activity, reducing power and total phenolic content of some lichen species. Fitoterapia, 76(2), 216–219. https://doi.org/10.1016/j.fitote.2004.05.012
Povoa-Violante, I. M. P., Hamerski, L., Garcez, W. S., Batista, A. L., Chang, M. R., Pott, V. J., & Garcez, F. R. (2012). Antimicrobial activity of some medicinal plants from the cerrado of the central-western region of Brazil. Brazilian Journal of Microbiology, 43(4), 1302–1308. https://doi.org/10.1590/S1517-83822012000400009
Prahastuti, S., Hidayat, M., Hasiana, S., Widowati, W., Amalia, A., Qodariah, R., Rizal, R., Kusuma, H. W., & Khoiriyah, Z. (2019). Ethanol extract of jati belanda (Guazuma ulmifolia L.) as therapy for chronic kidney disease in vitro model. Journal of Reports in Pharmaceutical Sciences, 8(2), 229–235. https://doi.org/10.4103/jrptps.JRPTPS_41_18
Rafi, M., Meitary, N., Anggraini-Septaningsih, D., & Bintang, M. (2020). Phytochemical Profile and Antioxidant Activity of Guazuma ulmifolia Leaves Extracts Using Different Solvent Extraction. Indonesian Journal of Pharmacy, 31(3), 171–180.
Rozqie, R., Diah, M., & Rukmi, W. (2014). The effect of Jati Belanda (Guazuma ulmifolia Lamk) leaves extract on histopathology of rat’s kidney. Tropical Medicine Journal, 2(1), 57–65.
Sanabria N., Utrera, N., (2022). Guácimo (Guazuma ulmifolia Lam): Fuente de Compuestos Bioactivos Beneficiosos para la Salud. Revista de Ciencia y Tecnología, 1(21), 115–126. https://scholar.googleusercontent.com/scholar?q=cache:a0lSXNDBkuIJ:scholar.google.com/+Guazuma+ulmifolia+usos+medicinales&hl=es&as_sdt=0,5
Senthil, P., Kumar, A. A., Manasa, M., Kumar, K. A., Sravanthi, K., & Deepa, D. (2011). Wound healing activity of alcoholic extract of “Guazuma ulmifolia” leaves on Albino Wistar rats. International Journal of Pharma and Bio Sciences, 2(4), 34–38.
Shekhawat, D.N. (2021). Guazuma Ulmifolia: A Review on its Traditional Uses, Phytochemistry and Pharmacology. International Journal of pharma and Bio Sciences, 12, 93-105.
Von Son-De Fernex, E., Alonso Díaz, M. Á., Mendoza de Gives, P., Valles de la Mora, B., Zamilpa, A., & González Cortazar, M. (2016). Actividad ovicida de extractos de cuatro especies de plantas contra el nematodo gastrointestinal Cooperia punctata. Veterinaria México OA, 3(2), 0–0. https://doi.org/10.21753/VMOA.3.2.365
Widowati, W., Prahastuti, S., Hidayat, M., Hasiana, S. T., Wahyudianingsih, R., Afifah, E., Kusuma, H. S. W., Rizal, R., & Subangkit, M. (2022). Protective Effect of Ethanolic Extract of Jati Belanda (Guazuma ulmifolia L.) by Inhibiting Oxidative Stress and Inflammatory Processes in Cisplatin-induced Nephrotoxicity in Rats. Pakistan Veterinary Journal, 42(3), 376–382.
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2024-01-01
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